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    GLP-1
    Stopping
    Maintenance

    Medical guide

    Can You Stop GLP-1? What Happens Then?

    What does research say about stopping GLP-1 treatment? Risks, strategies, and how to maintain your results.

    minutes reading time

    6 min

    Updated

    20 February 2025

    Reviewed by

    Dr. Dorél Lehrer

    Content

    Rx education

    Stopping GLP-1 treatment

    Dr. Dorél Lehrer

    Licensed Physician

    Quick answer

    The STEP 4 study shows that some weight regain occurs after stopping. Sustainable lifestyle habits are key. Some patients continue with maintenance dose. Planned tapering is recommended.

    DD

    Dr. Dorél Lehrer

    Licensed Physician

    Medical Director at Viktenheten
    Experienced in medical weight management

    Verifierad av Socialstyrelsen

    Medicinskt granskad: 20 February 2025

    Medical information, not medicine advertising

    This article is educational and does not replace individual care. Which medicine may be relevant is decided by a licensed doctor after medical assessment. Prescription issuing is included only when a doctor decides it is medically appropriate.

    Medicinskt granskad av Dr. Dorél Lehrer, 20 February 2025. Innehållsrisk: rx-education.

    Many wonder what happens when treatment ends. The STEP 4 study provides important insight on this.

    What Does STEP 4 Show?

    Patients who stopped semaglutide after 20 weeks regained approximately two-thirds of their weight during the following year. Those who continued maintained their weight loss.

    Why Does Regain Occur?

    Obesity is a chronic disease with biological mechanisms that counteract weight loss. When the medication is removed, hunger signals return.

    Strategies for Success

    Build sustainable diet and exercise habits during treatment. Plan the ending together with the care team. Consider maintenance dose or longer treatment.

    Frequently asked questions

    Do I have to take the medication forever?
    Not necessarily. Some manage without it after establishing new habits. Others need maintenance treatment.
    How do we plan the ending?
    We discuss this when the time comes and create an individual plan with follow-up.

    Sources and Further Reading

    Denna artikel är medicinsk information skriven av Dr. Dorél Lehrer, Licensed Physician. Eventuell behandling sker efter individuell bedömning av legitimerad läkare.

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